1032-HIV-1 Signalling Remodels Nuclear Pores

Paper Talk · May 26, 2026 · 24m

This research reveals that HIV-1 overcomes infection barriers in resting T cells by using cell-to-cell spread to trigger internal signaling. While free-floating virus particles fail to infect these cells, direct contact between cells initiates CD4–LCK signaling, which activates the enzyme CDK1. This process remodels nuclear pores, effectively opening a gateway for the viral capsid to enter the nucleus. By reorganizing the nuclear pore complex, the virus bypasses the need for full T cell activation. These findings explain how HIV-1 successfully spreads within the body's immune system by…