1080-Sexual Dimorphism in the Drosophila Brain
This article presents a high-resolution single-cell transcriptomic atlas of the adult Drosophila central brain to investigate the molecular foundations of sexual dimorphism. The authors demonstrate that sex-based differences in the brain are not the result of global genetic reprogramming but are instead driven by the transcription factors Doublesex and Fruitless, which tune specific developmental lineages. By linking these molecular profiles to anatomical identities, the study reveals that birth order serves as a vital axis for sexual differentiation. Specifically, sex-biased neuronal…
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