Dr Andrew Kiselica - Why "Normal" Cognition Is Hindering Preclinical Alzheimer’s Trials

Dementia Researcher Blogs · Apr 15, 2026 · 8m

Dr Andrew M. Kiselica, narrating a new blog he wrote for the Dementia Researcher website.

Why are preclinical Alzheimer’s trials struggling to show results? Andrew and colleagues argue the issue may not just be biology or timing, but how we define “normal.” By grouping cognitively unimpaired individuals together, trials overlook meaningful differences in subtle symptoms. This blog explores how recognising objective subtle cognitive decline, supported by digital tools and refined measures, could improve participant selection and increase the chances of detecting real treatment effects.

Find…