408-An expanded registry of cis-regulatory elements
The paper details the expansion of the ENCODE registry, a comprehensive catalog of candidate cis-regulatory elements (cCREs) used to study gene expression in humans and mice. Researchers nearly tripled the registry's size to include 2.37 million human elements by utilizing advanced computational methods and diverse datasets across hundreds of cell types. This updated resource introduces new functional categories, such as silencers and latent enhancers, which were validated through large-scale assays like STARR-seq and CRISPR perturbations. The sources demonstrate the registry's utility in…
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