1147-Microbiota-Gut-Brain and Habitual Coffee Consumption

Paper Talk · Jun 18, 2026 · 24m

This study explores the microbiota-gut-brain axis by comparing habitual coffee drinkers to non-drinkers and tracking the effects of caffeine withdrawal and reintroduction. Researchers discovered that regular coffee intake significantly alters fecal microbiome composition, specifically increasing species like Cryptobacterium while decreasing neuroactive metabolites such as GABA. Behavioral data revealed that while coffee drinkers showed higher impulsivity and emotional reactivity, reintroducing coffee—especially decaffeinated versions—linked to improved memory and sleep quality. The findings…