105-Nerve-to-cancer transfer of mitochondria
This paper details the mechanism by which neurons enhance the metastatic potential of cancer cells through metabolic support. Specifically, the researchers demonstrate that cancer-associated neurons transfer their mitochondria to adjacent cancer cells, thereby increasing the cancer cells' metabolic efficiency and oxidative phosphorylation (OXPHOS) capacities. Using a novel genetic reporter, MitoTRACER, the study confirms that these mitochondria-recipient cancer cells exhibit increased stemness and resilience against stresses like oxidative and shear stress, which are crucial for metastatic…
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