1403-Roles of PKM2 in Retinal Homeostasis and Survival
This research investigates the vital role of the PKM2 enzyme in maintaining retinal health and metabolic stability. By examining mouse models, the study reveals that PKM2 is essential for the survival and structural integrity of both photoreceptors and the retinal pigment epithelium (RPE). The authors demonstrate that a deficiency in PKM2 disrupts energy production, impairs the visual cycle, and causes the mislocalization of the protein rhodopsin. Furthermore, the findings suggest that the loss of this enzyme accelerates retinal degeneration, particularly in genetic backgrounds associated…
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