1130-The Microbiota-SNHG9-MAS Axis in Liver Protection

Paper Talk · Jun 14, 2026 · 17m

This research identifies a novel gut-liver axis where the long non-coding RNA SNHG9 protects against drug-induced liver injury (DILI), specifically from acetaminophen overdose. The study demonstrates that the gut microbiota modulates hepatic SNHG9 levels through the metabolite HMB, which is primarily produced by bacteria like Lactobacillus plantarum. Mechanistically, SNHG9 binds to the protein IMP2 to destabilize MYC mRNA, thereby removing a transcriptional repressor and increasing the expression of the MAS receptor. This activation triggers MAS-mediated autophagy, a cellular recycling…