1319-Geometric Constraints on Mammalian Cortical Connectomes

Paper Talk · Jul 22, 2026 · 26m

This research introduces the Geometric Eigenmode Model (GEM), a framework establishing that the physical shape and geometry of the brain fundamentally dictate its complex wiring patterns. By applying neural field theory, the authors demonstrate that the mammalian cortical connectome is organized to support resonant standing waves of activity, prioritizing connections that facilitate these natural geometric vibrations. This model accurately replicates the topological and topographical features of brain networks across five species, including humans, macaques, and mice. The findings suggest…