383-FlashDeconv: Atlas-Scale Spatial Deconvolution

Paper Talk · Jan 7, 2026 · 17m

FlashDeconv is a newly developed computational framework designed for high-speed, accurate cell type deconvolution in large-scale spatial transcriptomics. Unlike traditional methods that rely on gene variance—which often ignores rare cells—this tool uses leverage-score importance sampling to preserve distinct biological signals regardless of their abundance. By employing randomized sketching, the system compresses massive datasets to allow for analysis on standard hardware in seconds rather than days. The researchers used this efficiency to identify a "resolution horizon" between 8 and 16…