Latest / Skin Anarchy / The Global Future of Aesthetic Medicine with AMWC Americas Leaders Ft. Dr. Steven Dayan, Dr. Sabrina Fabi, & Dr. Nathan LeBrasseur

Transcript

The Global Future of Aesthetic Medicine with AMWC Americas Leaders Ft. Dr. Steven Dayan, Dr. Sabrina Fabi, & Dr. Nathan LeBrasseur · Skin Anarchy

• 0:00
  SPEAKER_00: Hey guys, welcome back to Skin Anarchy.
• 0:02
  SPEAKER_00: Today we're going to be talking about an amazing, amazing aesthetics conference.
• 0:05
  SPEAKER_00: It is the world's best conference in aesthetic medicine.
• 0:08
  SPEAKER_00: And so without further ado, I would like to uh welcome back Dr.
• 0:11
  SPEAKER_00: Diane and Dr.
• 0:12
  SPEAKER_00: Fabi, who are coordinators of the conference.
• 0:14
  SPEAKER_00: And you know, they're on the advisory committee.
• 0:16
  SPEAKER_00: So welcome.
• 0:17
  SPEAKER_00: I'm so excited to host both of you.
• 0:19
  SPEAKER_01: Thank you so much for having us.
• 0:20
  SPEAKER_03: Well it's great to be back with you.
• 0:22
  SPEAKER_00: It's so great to have this opportunity to talk to both of you about the scope of this conference because there's so much that is covered and there's so much amazing insights, and people get to learn so much.
• 0:33
  SPEAKER_00: So I would love, Dr.
• 0:34
  SPEAKER_00: Dan, if you could kind of start us off, like tell us a little bit about what you think you know AMWC really stands for in the space and like the aesthetic space and overall, I guess, in general.
• 0:44
  SPEAKER_03: Well, AMWC is a big brand of meetings, and they're all around the world.
• 0:49
  SPEAKER_03: And we've been going to AMWC meetings.
• 0:51
  SPEAKER_03: The big one, which is in Monaco every year, is the real exciting one where tens of thousands of people show up and it's the latest and greatest in aesthetic treatments, mostly non-surgical treatments.
• 1:00
  SPEAKER_03: And it's one of the best conferences of the year for, and Serena and I love going there.
• 1:04
  SPEAKER_03: But four years ago, right before COVID, they started a version of it in America, in Miami.
• 1:10
  SPEAKER_03: And I helped uh originate that first conference.
• 1:12
  SPEAKER_03: We called it the Miami Cosmetic Surge at the time.
• 1:14
  SPEAKER_03: It's now the name has been changed to AMWC Americas.
• 1:18
  SPEAKER_03: So it's nothing that's brand new, but it's it's still early on in its evolution.
• 1:23
  SPEAKER_03: And every year it gets better and better.
• 1:25
  SPEAKER_03: It's at the Turnberry Hotel in Miami, and it draws doctors from all across the US, but a lot from South America who love coming to Miami.
• 1:34
  SPEAKER_03: And we get a lot of insights.
• 1:36
  SPEAKER_03: It also draws doctors from Europe because AMWC is such a big brand of name for meetings that people know the name and they want to come to the US to participate.
• 1:44
  SPEAKER_03: And every time I go to one of these meetings, I get an opportunity to learn so much from my colleagues about what's new in many parts of the world that, you know, we're not at or we don't have first sight on some of their procedures and some of their products.
• 1:55
  SPEAKER_00: Yeah, that's I mean, that's amazing though, that it covers such a wide scope, you know, especially for anyone who's like new to aesthetics.
• 2:01
  SPEAKER_00: If you're like a new professional in the space, that it's, you know, invaluable resource.
• 2:05
  SPEAKER_00: Dr.
• 2:05
  SPEAKER_00: Fabi, I'd love to uh hear from you as well about, you know, what is like your favorite part of the Miami conference, especially.
• 2:11
  SPEAKER_01: I think that one of my favorite parts of AMWC in general is that you do get to mingle with colleagues from all over the world, where many of them generally have access to injectables, procedures, devices uh that we may not necessarily have in the United States because it's launched elsewhere first.
• 2:32
  SPEAKER_01: And so we get that firsthand uh knowledge from them, their experience as either investigators or now users of these products and procedures, that you really wouldn't be able to get at a US conference where you mainly have US doctors because it hasn't become available yet here.
• 2:48
  SPEAKER_01: And so that way we can kind of learn what we need to watch out for, maybe shortcomings of some of the procedures that might be out there, and then also things to be really excited about.
• 3:00
  SPEAKER_01: Along those lines, we learn about science and of different perhaps topicals or potentials for topicals, as well as um maybe the direction that aesthetics might be going globally that we may not necessarily have full scope of when we just attend a US-based conference.
• 3:20
  SPEAKER_01: So that's probably you know some of the things that I really appreciate when I go to AMWC.
• 3:24
  SPEAKER_03: If I can add on, I I think I echo what Dr.
• 3:27
  SPEAKER_03: Fabi said, but also one of the benefits of this meeting is that it's available to all levels of providers.
• 3:32
  SPEAKER_03: So you'll see those who really want to nerd out on the science, as well as some of the novices who are coming to kind of just get put their test their feet in the water, so to speak.
• 3:41
  SPEAKER_03: And one of the best sessions, I think one of the most popular sessions always is the anatomy section, where we have a live cadaver dissection and you you get to see that being done and we talk through it.
• 3:51
  SPEAKER_03: It's about a three-hour course, and throughout that, the room's packed, and you really get to understand like what you're doing when you're treating these patients.
• 3:59
  SPEAKER_00: That's really interesting.
• 4:00
  SPEAKER_00: I feel like they've gotten rid of cadaver dissections now in medical school.
• 4:03
  SPEAKER_00: So that's really a great opportunity for someone to, you know, see it if you've if you haven't seen it in medical school.
• 4:09
  SPEAKER_00: I know my brother is 10 years younger than me, and he's like, we never even got to do it, you know, we didn't have the exposure.
• 4:14
  SPEAKER_00: That's really great.
• 4:15
  SPEAKER_01: And it's one of the best parts of medical school.
• 4:17
  SPEAKER_00: It is.
• 4:17
  SPEAKER_00: I know.
• 4:18
  SPEAKER_00: That was my favorite part.
• 4:19
  SPEAKER_00: That's really cool.
• 4:20
  SPEAKER_00: Um, I, you know, I'm very interested though, because I'd love to get both of your perspectives on your specific specialties and what you love the most about the conference from that angle.
• 4:28
  SPEAKER_00: Because I know, Dr.
• 4:29
  SPEAKER_00: Dion, from a surgical perspective, what are some of the things that you really look forward to every year, you know, in terms of like just, you know, the groundbreaking stuff that we see at the conference from surgical perspective?
• 4:40
  SPEAKER_03: So as far as surgical, this this conference in Miami is not surgery is not primary.
• 4:45
  SPEAKER_03: There's one we do in Vegas in the end of May, which is more surgical focused.
• 4:49
  SPEAKER_03: Having said that, there are quite a few surgeons here who are really trying to figure out how they add non-surgical procedures to their armamentarium.
• 4:56
  SPEAKER_03: And it's one of the ways in which I learn when is it time to do surgery, when is it time to do non-surgical procedures, and how do I fit those two together.
• 5:04
  SPEAKER_03: And also I find a lot of things that I can add on to my surgical procedures, whether it's a laser, uh, adjunct afterwards, or topical skincare, which you know, Serena and I are particularly really invested in right now, is how to add on topicals to really make our results even better.
• 5:18
  SPEAKER_00: That's fascinating.
• 5:19
  SPEAKER_00: Dr.
• 5:19
  SPEAKER_00: Fabi, I'm I'm would love for you to kind of go off of that because I know in dermatology there's just so much happening.
• 5:25
  SPEAKER_00: The scope is broadening so much, I feel like, you know, for the whole field.
• 5:28
  SPEAKER_00: And so a conference like this, I think is such a great place, you know, for someone to learn, obviously, but then also discover.
• 5:33
  SPEAKER_00: I mean, what are your thoughts on that in terms of from the dermatology perspective?
• 5:37
  SPEAKER_00: Like, what can people really expect and and gain from attending this kind of event?
• 5:41
  SPEAKER_01: I love that, you know, in the word inherently, it's an anti-aging medicine world congress, right?
• 5:46
  SPEAKER_01: And so there's a focus on anti-aging.
• 5:49
  SPEAKER_01: What we do in our practice every single day as aesthetic dermatologists or facial plastic surgeons is of course the aesthetic element of it, making someone look and feel more beautiful.
• 6:00
  SPEAKER_01: But a part of that is also youth that is lost.
• 6:03
  SPEAKER_01: And so to a degree, you're trying to restore some of that youth, uh, which is not just in the ability that our procedures are able to perhaps stimulate stem cells or decrease cellular senescence, but also in a more holistic approach that sometimes hormones can provide, um, whether topically or systemically, or in the way that perhaps other modalities, now peptides and even macronutrients and micronutrients, whether in an injectable form or whether uh systemically taken, can also uh help aid and support our patients' longevity journey.
• 6:40
  SPEAKER_01: And so I do like to have a more holistic approach when I deal with my patients because I do recognize that what I do is limited.
• 6:47
  SPEAKER_01: You can have beautiful results, but there is no doubt that someone who is more hormonally supported, optimized nutritionally, is always going to look better in the end.
• 6:56
  SPEAKER_01: And patients want to look and feel better after 15 years of doing aesthetic procedures.
• 7:01
  SPEAKER_01: So I feel that this conference does have sessions and lectures that sometimes provide that information where I may not necessarily see that in just dermatologic conferences or facial plastic surgery conferences alone.
• 7:17
  SPEAKER_00: That's really fascinating that you you brought this up because I feel like right now we're in a time where everything's online.
• 7:21
  SPEAKER_00: You know, there's so many courses, so many certifications that are online based.
• 7:25
  SPEAKER_00: And I think it's important to talk about.
• 7:27
  SPEAKER_00: And I'd love to get both of your insights on this is why is a conference like this so important to attend versus just relying on these like online certifications or online continued uh education platforms.
• 7:39
  SPEAKER_00: Dr.
• 7:39
  SPEAKER_00: Down, maybe you could start us off there.
• 7:41
  SPEAKER_03: Sure.
• 7:41
  SPEAKER_03: You know, the online platforms, while they're awfully attractive, they're not comprehensive enough.
• 7:46
  SPEAKER_03: And you can't just dabble.
• 7:48
  SPEAKER_03: You have to really invest into this process.
• 7:49
  SPEAKER_03: If you want to be an aesthetic physician at the highest level or an aesthetic provider, you've got to spend the time, energy, and effort.
• 7:55
  SPEAKER_03: And it doesn't just come with an online course.
• 7:57
  SPEAKER_03: I think hands-on is super um helpful.
• 8:00
  SPEAKER_03: And going to conferences like this where you can see the way that experts are doing it.
• 8:04
  SPEAKER_03: You know, you keep in mind that lots of times these courses that are online, they may be um presenting just one way to do it.
• 8:09
  SPEAKER_03: You're not getting multiple opinions.
• 8:11
  SPEAKER_03: You're also maybe getting it just on label, whereas you want to hear from experts who are doing it multiple different ways.
• 8:16
  SPEAKER_03: Also, doctors in different parts of the world are doing differently.
• 8:18
  SPEAKER_03: Also, some of these products are launched in different parts of the world first.
• 8:22
  SPEAKER_03: So there's more experience in those parts of the world.
• 8:24
  SPEAKER_03: And here you get a chance to work closely with a lot of physicians and providers who are heavily experienced.
• 8:29
  SPEAKER_03: So I think you just can't beat that.
• 8:30
  SPEAKER_03: And then you get to see the you get to see the cadaver anatomy at the same time.
• 8:34
  SPEAKER_03: So not just one conference is going to make you proficient.
• 8:37
  SPEAKER_03: It's something that you really have to take a lot of time.
• 8:39
  SPEAKER_03: You have to learn it didactically, but you also need to spend time going to these conferences.
• 8:43
  SPEAKER_03: So if you're really committed to it, I would suggest going to a conference like this.
• 8:46
  unknown: Dr.
• 8:47
  SPEAKER_00: Fami, I'd love for you to also uh tell us here, because you had brought brought up longevity, uh, which was really very fascinating to me.
• 8:54
  SPEAKER_00: Um, from that perspective, I'd love to hear more.
• 8:56
  SPEAKER_01: Right, because many procedures generally just focus on stimulating one cell or in stimulating some, you know, constituents of a particular tissue in dermatology, let's say it could be collagen and elastin, but we don't know how long that stimulation takes place for.
• 9:14
  SPEAKER_01: And we also know that the environment that that stimulation takes place in influences how long the stimulation effect may continue for, right?
• 9:25
  SPEAKER_01: And so it's kind of like putting flowers on soil.
• 9:28
  SPEAKER_01: If the soil is not optimized, if the environment is not optimized, those flowers may not flourish to their full potential.
• 9:35
  SPEAKER_01: And so longevity, I think, is heavily driven on at least from the procedures that we do and the results that we're getting from our procedures, the longevity of our procedures, even, is really optimizing the person and optimizing their health.
• 9:48
  SPEAKER_01: And so there's more and more, of course, it's beyond just diet and exercise.
• 9:53
  SPEAKER_01: It's also hormonal status.
• 9:55
  SPEAKER_01: Perhaps we'll find out, you know, in the long term, the influence of GLPs and decreasing overall inflammatory status.
• 10:03
  SPEAKER_01: Um, because this ultimately, that inflammation, inflammation directly links to aging.
• 10:08
  SPEAKER_01: And GLPs have an effect on about four different pathways of cellular aging that we're aware of.
• 10:14
  SPEAKER_01: If we use uh the paper and cell to guide us, there's about 16 different pathways.
• 10:19
  SPEAKER_01: There's very few things that we can do, injectable-wise or topical-wise, that can really influence many of those pathways, unless you're dealing with hormones or you're potentially dealing with GLPs.
• 10:33
  SPEAKER_01: And so that's that's why optimizing the environment can get greater longevity from our results.
• 10:40
  SPEAKER_00: Yeah, that's really fascinating.
• 10:41
  SPEAKER_00: That's I I need to read that paper that you're talking about.
• 10:44
  SPEAKER_00: I don't think I caught it.
• 10:45
  SPEAKER_01: Yeah.
• 10:45
  SPEAKER_01: They just did an update 2025.
• 10:47
  SPEAKER_00: Wow.
• 10:47
  SPEAKER_00: Thank you so much, Dr.
• 10:48
  SPEAKER_00: Fabi.
• 10:49
  SPEAKER_00: Yeah, I mean, GLPs is definitely, I mean, I think that's a great example that you brought up because there's so much happening right now in the longevity space that I don't think in aesthetic medicine we're even like looking at it.
• 11:00
  SPEAKER_00: Like I know, like for people who are interested, right?
• 11:02
  SPEAKER_00: You're you guys are immersed in the field.
• 11:04
  SPEAKER_00: And so you see this, I think, more than maybe like a medical student or a resident or fellow.
• 11:08
  SPEAKER_00: But like if you're just now getting into it, such a vast ocean, you know, in terms of like what's out there and what are the potentials.
• 11:15
  SPEAKER_00: So that I could see that be so helpful for someone, you know, to go to a conference like this, get a footing in that kind of science and that knowledge.
• 11:22
  SPEAKER_00: That's huge.
• 11:23
  SPEAKER_03: We're all seeing a merging of like sexual health and wellness, holistic health and aesthetics, they're all kind of coming together right now.
• 11:28
  SPEAKER_03: Yeah, and we're all kind of leading to the same point.
• 11:30
  SPEAKER_03: So it's really interesting to be part of that world as that happens.
• 11:33
  SPEAKER_00: Yeah.
• 11:34
  SPEAKER_00: No, this is really interesting because, you know, also you brought up international.
• 11:37
  SPEAKER_00: I love that you you both brought up the international component of medicine.
• 11:41
  SPEAKER_00: I think this is something that's never really discussed in actual continued medical education.
• 11:46
  SPEAKER_00: And I'd love for you to expand on this a little bit because I feel like when I was in my training, I learned so much from like Nigerian doctors, for example.
• 11:53
  SPEAKER_00: I had one amazing physician that taught me so much.
• 11:56
  SPEAKER_00: And I was like, I feel like you you summed a year worth of training up, you know, in a month when I trained with him.
• 12:01
  SPEAKER_00: And so something like that, like the international component, like what are your thoughts on that for especially young doctors and attending a you know event like this and what that means for their overall training?
• 12:11
  SPEAKER_03: You know, about three years ago, Sabrina and I did a whole world tour and we went to six different countries and we we studied aesthetic medicine in those countries and we compared it to the US.
• 12:20
  SPEAKER_03: So we went to Africa.
• 12:21
  SPEAKER_03: We treated an African patient in Africa with an African doctor, and an African-American patient in America with an American doctor.
• 12:27
  SPEAKER_03: So we compared and contrast how we treat those patients in those different parts of the world.
• 12:31
  SPEAKER_03: It was absolutely fascinating.
• 12:32
  SPEAKER_03: We went to India, we went to Asia, we went to Europe, we went to South America, the Middle East, and then we wrote it all up and we published it.
• 12:38
  SPEAKER_03: It's called Diversity and Aesthetics.
• 12:40
  SPEAKER_03: And then you can get those articles if you want to see it.
• 12:42
  SPEAKER_03: But I'll tell you that Sabrina and I came back, I think we came back as different doctors, just because you see how things are done differently in different parts of the world.
• 12:49
  SPEAKER_03: And you recognize that we all have an aesthetic bias because we're all trained one way.
• 12:53
  SPEAKER_03: But when you go to other parts of the world that have Eastern influences or native influences, you start to see that they look at things a little bit differently and a little bit more holistically.
• 13:02
  SPEAKER_03: And the way they look at the anatomy might be different than how we look at the areas of the body they treat.
• 13:06
  SPEAKER_03: And the products that they use are also a little bit different, which means that maybe they use the products differently.
• 13:11
  SPEAKER_03: I remember the first time I went to China and they were using Botox, and they're like, um, they're putting it in the in the masseters.
• 13:17
  SPEAKER_03: I'm like, wait, why are you putting it there?
• 13:19
  SPEAKER_03: Don't you put it up here in the globellar area and between the eyebrows?
• 13:22
  SPEAKER_03: Like, no, we put it here.
• 13:23
  SPEAKER_03: And then we're talking about fillers.
• 13:24
  SPEAKER_03: And I'm like, okay, you put fillers in the nasal labifold.
• 13:27
  SPEAKER_03: They go, no, we put it in the nose.
• 13:28
  SPEAKER_03: And it was like we were completely on different planes, the way they treat faces in Asia versus the way we treat faces in the US.
• 13:34
  SPEAKER_03: So, anyways, like you come back a better doctor because you expand your reference range.
• 13:38
  SPEAKER_03: And anytime you expand your reference range, it changes where you fall because you like the average of all that big expanded reference range, and you become a better physician and a better aesthetic aesthetic physician, in my opinion.
• 13:49
  unknown: Dr.
• 13:49
  SPEAKER_00: Down, just to wrap it up, I just want to, you know, get a few more thoughts from you about, you know, in terms of just continued medical knowledge, you know, like I feel like that is the key.
• 13:59
  SPEAKER_00: And I think this conference and everything that I've learned about AMWC, it stands for this idea of like never stop learning.
• 14:06
  SPEAKER_00: You know, so I'd love for you to offer us some like just words of wisdom on this topic, you know, especially for all the young physicians out there that are just starting their careers off.
• 14:13
  SPEAKER_00: You know, anything you can tell us that we should know.
• 14:16
  SPEAKER_03: Well, there's no better way to defeat prejudices, whether against your past feelings and science or or any type of prejudice than education.
• 14:24
  SPEAKER_03: It if it breaks down all barriers.
• 14:26
  SPEAKER_03: And I think that's important.
• 14:27
  SPEAKER_03: Education is the cornerstone to medicine.
• 14:30
  SPEAKER_03: It's part of our Hippocratic oath.
• 14:31
  SPEAKER_03: When we decide to become doctors, we we pledge ourselves to always teach and we have to always learn.
• 14:36
  SPEAKER_03: And medicine is constantly changing.
• 14:37
  SPEAKER_03: Whatever I learned in medical school is completely irrelevant now for the most part.
• 14:41
  SPEAKER_03: Some of those foundation, those basics are still there, but the actual practice of medicine completely changes.
• 14:47
  SPEAKER_03: And that's one of the reasons why we have to continue to educate ourselves and CME or continual medical education is something that's part of our licensing.
• 14:55
  SPEAKER_03: So for physicians and nurses and PAs, continuing medical education is a very critical component to not only staying within regulations because you have to do it, but also becoming a better physician.
• 15:07
  SPEAKER_03: So I think we should learn.
• 15:08
  SPEAKER_03: And likewise, I think we have a responsibility to teach those after us as well.
• 15:13
  SPEAKER_03: And I think you see that flourishing at a conference like AMWC, where you have people just coming there to learn.
• 15:19
  SPEAKER_03: And it's for the betterment of the field and the betterment of our patients.
• 15:22
  SPEAKER_00: I love that.
• 15:23
  SPEAKER_00: Well, I'm really excited about the conference.
• 15:25
  SPEAKER_00: And for all of our listeners, uh, you guys can find all the information in the show notes to check it out.
• 15:29
  SPEAKER_00: But Dr.
• 15:30
  SPEAKER_00: Dan, thank you so much.
• 15:30
  SPEAKER_00: This has been so great.
• 15:32
  SPEAKER_00: And I'm really excited to see uh how many people show up and just all the wonderful things at the conference.
• 15:37
  SPEAKER_03: I look forward to seeing you and all the others who are going to be there.
• 15:39
  SPEAKER_03: It's always a great, it's a fun time.
• 15:41
  SPEAKER_03: I'm excited.
• 15:42
  SPEAKER_03: Take care.
• 15:43
  SPEAKER_00: Today we have Dr.
• 15:44
  SPEAKER_00: Labrasser with us, who is going to be the keynote speaker at the Miami AMWC conference, and he will be really teaching about longevity.
• 15:52
  SPEAKER_00: And so welcome, Dr.
• 15:53
  SPEAKER_00: Labrasser.
• 15:54
  SPEAKER_00: I'm so excited to kind of pick your brain a little bit and learn about this conference and your work.
• 15:59
  SPEAKER_00: I mean, I'd love to if you could tell us about, you know, your focus in longevity medicine.
• 16:04
  SPEAKER_02: Yeah, well, it's great to be here, and I'm really looking forward to the conference.
• 16:07
  SPEAKER_02: It's not the typical um audience that I speak to.
• 16:10
  SPEAKER_02: So it's good to kind of spread our news and share what we're learning with a larger group and a more diverse group.
• 16:17
  SPEAKER_02: And um, I have an incredible um job.
• 16:19
  SPEAKER_02: So I have the privilege of directing the Robert Narlene Co God Center on Aging at Mayo Clinic.
• 16:24
  SPEAKER_02: And we're really um a highly translational group, as you might expect, meaning that we do kind of very fundamental basic discovery science in cells and then model organisms and then really try to understand what is aging, what is this process that we all experience, and then bring that information into um models where we can test new ideas and interventions and ultimately translate those uh into the clinic, which I would argue we do better than anybody else in the world at Mayo Clinic.
• 16:51
  SPEAKER_02: So so we're learning a lot.
• 16:53
  SPEAKER_02: And you know, we I think we all fully appreciate that aging is by far the greatest risk factor for the overwhelming majority of chronic diseases.
• 17:00
  SPEAKER_02: And if we can understand that process better, we can ultimately envision interventions to delay age-related diseases as a group, right?
• 17:07
  SPEAKER_02: And and I can't think of a better way to fundamentally transform human health.
• 17:11
  SPEAKER_00: I'm glad you opened with that because you know, I noticed that your work does focus on like cellular senescence.
• 17:16
  SPEAKER_00: And this is we it's become so buzzworthy, you know, in the last like I think even one year or two years.
• 17:22
  SPEAKER_00: I've noticed people are now making it a mainstream term, which is very exciting, I think, for any scientist out there to hear that.
• 17:28
  SPEAKER_00: But, you know, I would love to get your take on like where do you think us, like just normal people, you know, um, what should we know about cellular senescence in terms of its actual, like the understanding we should have about, you know, how it plays into overall health and just every day.
• 17:44
  SPEAKER_02: Yeah, I can't blame you for asking the question that way because even as scientists who know this incredibly well, we still kind of struggle with really understanding the cell fate.
• 17:54
  SPEAKER_02: And, you know, we should really think of aging as our cells in our body undergoing different forms of wear and tear.
• 17:59
  SPEAKER_02: Uh aging is, and as a law of physics, it's it's entropy, right?
• 18:03
  SPEAKER_02: And and that that wear and tear leads to different forms of damage.
• 18:06
  SPEAKER_02: And sometimes our cells are really good at repairing that damage and they function perfectly and there's no harm.
• 18:11
  SPEAKER_02: Other times they undergo really extreme damage and they they die, right?
• 18:16
  SPEAKER_02: So those cells are lost.
• 18:17
  SPEAKER_02: But there's this interesting kind of middle ground that cells persist and and they're not labile or inactive, but they're actually just the opposite.
• 18:25
  SPEAKER_02: They're incredibly active influencers over their surrounding environment and the body at large.
• 18:32
  SPEAKER_02: So so these cells have been referred to as zombie cells, and I think part of that is because they're damaged and they look different, they behave different, they spread, but but it's really they're the these active players in health and function because factors that they elicit or release into our bodies can really wreak havoc.
• 18:48
  SPEAKER_02: And uh before I get too far ahead of myself, I should note that I think senescence is always a good thing.
• 18:52
  SPEAKER_02: You have senescent cells, I have senescent cells, individuals much younger than us have senescent cells, and that's to protect us from the growth and spread of cancers.
• 18:59
  SPEAKER_02: But as we get older, we're less effective at clearing those cells from our system, they start to accumulate, and that's when we really see them causing harm and damage.
• 19:06
  SPEAKER_00: Yeah, that's really fascinating because, you know, I think it I always worry about longevity becoming a buzzword, you know, and that's why I asked you about that, because I think that, you know, with cellular senescence, one of my biggest question marks has always been like, you know, well, how do we define a senescent cell, you know, and are we there yet?
• 19:21
  SPEAKER_00: You know, have we really found all of the markers that we would say this is a quantitative representation of senescence?
• 19:28
  SPEAKER_00: And so what are your thoughts on that in terms of the progress of the field at large?
• 19:32
  SPEAKER_02: Yeah, I think we made pref just remarkable progress over the past decade.
• 19:35
  SPEAKER_02: So I will tell you, and we started in this space, you know, our landmark paper on showing that these cells really do cause damage to multiple organ systems was 2011.
• 19:45
  SPEAKER_02: And since that time, we've developed really a rich way of characterizing what truly is a senescent cell.
• 19:52
  SPEAKER_02: And we now sometimes refer to those as core properties of senescence or major hallmarks of a senescent cell, where we see that they have features of growth arrests, so they're no longer dividing or replicating.
• 20:02
  SPEAKER_02: They have upregulation of this, what we call senescence associated secretory phenotype, which is the fact that these cells produce um so many different factors that can influence inflammation and tissue remodeling and degeneration and compromise regeneration.
• 20:16
  SPEAKER_02: And then they turn on these pro-survival factors.
• 20:18
  SPEAKER_02: Again, they're they're damaged, and you think they would just go away, but but they don't.
• 20:21
  SPEAKER_02: They survive and then they have these different histological features and hallmarks.
• 20:24
  SPEAKER_02: So it does take um a rich understanding of the biology and kind of a very good toolkit to identify a senescent cell.
• 20:32
  SPEAKER_02: And that's what's caused a little bit of confusion, I think, is that the senescent cells that might occur in my liver or my kidney or my lungs could be very different than the senescent cells in my skin.
• 20:41
  SPEAKER_02: And I think that's created a little bit of confusion and back and forth in our field, but it's it's a recognition that why would a hepatocyte in your liver or renal epithelial cell in your kidney or a fibroblast or a melanocyte, you know, in your skin look just like these other cell types.
• 20:54
  SPEAKER_02: So they all have their kind of unique characteristics, which is not surprising to me.
• 20:58
  SPEAKER_00: Right.
• 20:58
  SPEAKER_00: Yeah, that's very fascinating.
• 20:59
  SPEAKER_00: I'm glad you said that, you know, because I think that is uh I have noticed that people are trying to, I think because we're trying to wrap our head around it, that differentiation between cell types and then how organs kind of perform individually, I mean, that is getting kind of kind of pushed aside right now, you know.
• 21:14
  SPEAKER_00: And I think that's just the nature of right, like just academia, you want to focus so hard on one area and then kind of bring in.
• 21:20
  SPEAKER_00: But that translational component to me is incredibly fascinating.
• 21:23
  SPEAKER_00: Um, speaking of translational medicine, I would love to get your take on where you feel that a conference like AMWC really fits into kind of bridging this gap between physicians and the superclinical side of medicine and of obviously, you know, research and academia and translational understandings.
• 21:40
  SPEAKER_00: You know, how do you feel that this kind of conference benefits that?
• 21:43
  SPEAKER_02: Yeah, so I think I say this phrase probably far too often, but it it's really learning together.
• 21:47
  SPEAKER_02: And what we study in a dish or in a preclinical model or even in patient derived um biospecimens, we really need to kind of compare across these different formats to show that there's consistency.
• 22:00
  SPEAKER_02: To show that there's meaningfulness about what we're discovering and that there's a link to human health and function, right?
• 22:06
  SPEAKER_02: And that can be uh physical function, cognitive function, metabolic function, and skin health and function, right?
• 22:11
  SPEAKER_02: So it's really a matter of of connecting the pieces and connecting the dots and and and making the clinical audience really aware of what's happening behind the scenes.
• 22:20
  SPEAKER_02: And um, you know, I'm a huge advocate for healthy aging, right?
• 22:23
  SPEAKER_02: And uh I'm less concerned about living longer, but I I very much want to add life to our years versus years to our life.
• 22:30
  SPEAKER_02: And it's it's it's what are the what are the proactive things that we can do?
• 22:33
  SPEAKER_02: And there's no more influential voice than the clinicians at at kind of reinforcing the behaviors and the pillars of healthy aging.
• 22:40
  SPEAKER_02: So it's it's really important to have this dialogue and and also to kind of say, hey, this is what might be coming down the pike and keep an eye on this because this is really exciting.
• 22:47
  SPEAKER_00: Well, I mean, that's really fascinating because, you know, I think that is kind of the gap right now that I've noticed, you know, just from talking to people that are on more on the clinical side and they're they're wanting to bring longevity into their daily practice, you know, and and bring it in front of patients, you know, and really talk about it openly.
• 23:03
  SPEAKER_00: Where do you think the most promise is right now in the field where when it comes to that translational component, like where physicians can openly discuss this without fear-mongering or, you know what I mean?
• 23:15
  SPEAKER_00: Like because you know, patients get so worried so easily.
• 23:17
  SPEAKER_00: So, where do you think, what are some of the topics that I think are worth discussing in aesthetic medicine when it comes to longevity?
• 23:25
  SPEAKER_02: Yeah, you you guys may be ahead of the curve in a way, because I think part of this is really getting people to think about aging as a life course event.
• 23:34
  SPEAKER_02: You know, it's not that, hey, I celebrated my 65th or my 70th birthday strip, so I should start thinking about aging.
• 23:40
  SPEAKER_02: But instead, it's it's really recognizing and acknowledging that this is a life course event.
• 23:45
  SPEAKER_02: Yes, pick your parents wisely, but if you can't do that, you know, what what actions can I take today if I'm a teenager or a young adult or in my 30s or my 40s or my 50s to really improve my trajectory of aging, right?
• 23:57
  SPEAKER_02: That, you know, it's not a linear process, but it, but it's it's something that we experience throughout our life course.
• 24:02
  SPEAKER_02: And decisions we make today will affect us when we're 60 or 70 or 80.
• 24:06
  SPEAKER_02: And and that doesn't matter if you're you're 20 or you're you're 60, right?
• 24:09
  SPEAKER_02: So that's really important is it to expand that dialogue and have a meaningful conversation about it.
• 24:14
  SPEAKER_02: And um, as much as I get a bit of a cringe factor by all the social media in this space, I do think it's made this a household conversation and a conversation that a lot of individuals are having with their providers, which is great, right?
• 24:25
  SPEAKER_02: That, you know, I've I've been hearing all this buzz about aging.
• 24:27
  SPEAKER_02: You know, what what should I be doing about it today?
• 24:29
  SPEAKER_02: And and I think, you know, really getting clinicians comfortable with the knowledge that how powerful lifestyle choices are in this process, right?
• 24:37
  SPEAKER_02: I probably over-emphasize exercise as such a powerful way to counter the biology of aging, improve cognitive health, improve cardiovascular health, improve physical health, metabolic health, immune health, et cetera, et cetera, but also improve skin health, right?
• 24:50
  SPEAKER_02: Like, you know, these are systemic changes that influence all of our body systems.
• 24:54
  SPEAKER_02: And then nutritional choices have such a powerful influence.
• 24:57
  SPEAKER_02: Sleep, I think, is probably the hottest behavior that I think in the next few years is going to be discussed more and more.
• 25:02
  SPEAKER_02: We're kind of challenged with sleep quality and sleep hygiene because of all the distractions that we have.
• 25:07
  SPEAKER_02: And I'm guilty of that too, right?
• 25:09
  SPEAKER_00: I think we all are.
• 25:10
  SPEAKER_00: Yeah, yeah, yeah.
• 25:10
  SPEAKER_02: And then meaning and purpose, and and and and those pillars have to be addressed.
• 25:14
  SPEAKER_02: And if we don't address those pillars, we have a review article coming out where we have this awesome kind of image of uh a house on stilts, and those stilts are kind of nutrition, uh, exercise, sleep, and kind of meaning and purpose.
• 25:26
  SPEAKER_02: And without those pillars, no matter what you do to that house, right, it's kind of like painting the shutters.
• 25:30
  SPEAKER_02: It's not gonna provide stability and structure for you to age well.
• 25:34
  SPEAKER_02: So it's it's it's and and we can we we can all kind of advise on those things, and there's just such sound evidence um for fundamentals of of of healthy aging.
• 25:41
  SPEAKER_00: Yeah, I really I I like that analogy and I'm I'm excited to read your read your paper uh because you know, I think this is I I've seen this become a it's a great topic.
• 25:52
  SPEAKER_00: You're right.
• 25:52
  SPEAKER_00: It's social media is buzzing right now, but I've also seen that hesitancy on the clinical side.
• 25:56
  SPEAKER_00: Clinicians are they want to talk about it, but it's like, what do I talk about?
• 26:00
  SPEAKER_00: You know, and then there's all the biomarkers, there's all the tracking going on, and it's like, well, we don't not interpret any of this, you know, in a meaningful way yet.
• 26:08
  SPEAKER_00: So it's it's a lot.
• 26:09
  SPEAKER_00: So I think that's very helpful.
• 26:11
  SPEAKER_00: Yeah.
• 26:11
  SPEAKER_02: And I think this is that kind of just reinforces this.
• 26:13
  SPEAKER_02: Um, and and not every clinician can do this, but really pushing for organizations that have kind of the clinical expertise and the biological expertise to find ways to work together where how can we better match kind of clinical risk profiles on diagnostics, family history, imaging, et cetera, and bringing in this element of, you know, these are emerging aging biomarkers.
• 26:35
  SPEAKER_02: They're not all perfect, they're not all tested, but but how can we start to combine those things to get a better picture of of health?
• 26:41
  SPEAKER_02: And that's something I'm really excited about.
• 26:43
  SPEAKER_02: And, you know, I'll mention a little bit in the talk.
• 26:44
  SPEAKER_00: No, it's it's very, very exciting.
• 26:46
  SPEAKER_00: And I and I think, you know, just keeping the time in mind, I just want to ask you, uh, because, you know, this type of interdisciplinary meeting of the minds, I think is just such a it's a beautiful thing to see, first of all, in medicine and science, but also um for anybody who's new to like AMWC, for example, what's one thing that you think they should kind of come into this?
• 27:05
  SPEAKER_00: Like what mindset should you have when you're trying to understand all of the moving pieces of longevity medicine and figuring out where maybe you fit, you know, in the grand scheme of things, whether you're a clinician or a student.
• 27:18
  SPEAKER_02: Yeah, I th I think come with an open mind and curiosity.
• 27:21
  SPEAKER_02: And also, also, I think being um critical, right?
• 27:24
  SPEAKER_02: I I think science is a continuous process.
• 27:28
  SPEAKER_02: We I really push on transparency and how we do what we do and encouraging other people to replicate it because sometimes that doesn't happen and you know, mistakes do happen or misinterpretations happen.
• 27:38
  SPEAKER_02: So I think, you know, this is a complicated answer in a way, but I think come with a very open mind, but also being critical, uh asking good questions and being very thoughtful.
• 27:46
  SPEAKER_02: And, you know, I think it's really important to balance hope and hype.
• 27:49
  SPEAKER_02: I think we're all very hopeful, but there's so much hype you have to filter that out.
• 27:53
  SPEAKER_00: It's a great answer.
• 27:54
  SPEAKER_00: Thank you so much.
• 27:54
  SPEAKER_00: Um, I'm really excited about the meeting, and I can't wait to hear your talk.
• 27:58
  SPEAKER_00: And for, you know, everybody who is thinking about attending, please do.
• 28:02
  SPEAKER_00: This is such an amazing opportunity.
• 28:04
  SPEAKER_00: And I think, especially with longevity, like a field like longevity, I think it's rare to be able to learn about it in such depth.
• 28:10
  SPEAKER_00: So I I really am excited about this.
• 28:12
  SPEAKER_02: I'm excited too.
• 28:13
  SPEAKER_02: So um, thanks for the great questions and I look forward to seeing everybody um in Miami very soon.
• 28:17
  SPEAKER_00: Thank you.