1456-JMJD3 Modulates Benign Prostatic Hyperplasia
This research study identifies the histone demethylase JMJD3 as a critical driver of benign prostatic hyperplasia (BPH), a common condition in aging men. By analyzing human samples and utilizing advanced sequencing methods, the authors found that JMJD3 expression is significantly elevated in BPH tissues and can be triggered by inflammatory stimuli like LPS. Mechanistically, the protein promotes disease progression by removing repressive epigenetic marks at the TGF-β1 promoter, which in turn activates signaling pathways that boost cell proliferation and cycle progression. Experimental results…
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