1563-Metabolic Atlas of Human Cortical Development
This paper presents a comprehensive metabolic map of the developing human brain, focusing on how nutrient processing influences the maturation of various brain cells. The research highlights two specific chemical pathways, glycolysis and the pentose phosphate pathway, as essential drivers for the transformation of radial glia into specialized neural populations. By experimenting with cortical organoids, the authors discovered that altering glucose access or inhibiting key enzymes directly changes the ratio of different cell types produced. Notably, the study found that ribose could counteract…
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