1667-Serpins Drive Immune Evasion in Pancreatic Cancer

Paper Talk · Oct 12, 2026 · 15m

The paper investigate pancreatic ductal carcinoma (PDAC) and demonstrate how specific tumour-derived serpins, specifically SERPINE1 and SERPINB2, act as master organizers of the tumour microenvironment. Through advanced spatial functional genomics, researchers discovered that these serpins stabilize fibrin-rich extracellular matrices that physically exclude cytotoxic T cells while selectively retaining and programming immunosuppressive macrophages. Genetic knockout or pharmacological inhibition of these serpin pathways reduces tumor burden, remodels immune architecture, and significantly…