1230-Confined Neuronal Migration Induces DNA Damage
A study reveals that developing neurons experience significant DNA double-stranded breaks as they migrate through narrow spaces in the brain. Unlike cancer cells, which often suffer DNA damage due to nuclear envelope rupture, these neurons maintain their membrane integrity while experiencing mechanical stress. Researchers discovered that this damage is primarily linked to topoisomerase-IIβ activity and is typically resolved through non-homologous end-joining repair mechanisms. If these lesions are not properly fixed, the resulting genomic instability can lead to persistent DNA accumulation…
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