673-Endothelial Dysfunction as a Driver of Cancer Cachexia
This research article from Nature Cancer identifies a critical link between vascular health and the progression of cancer cachexia, the debilitating loss of muscle mass in cancer patients. Through various tumor models and human samples, the authors discovered that a reduction in muscle capillary density actually happens before visible muscle wasting occurs. The study pinpoints a specific biological pathway where tumors release a factor called activin A, which travels through the blood to suppress the protein PGC1α within the inner lining of blood vessels. This suppression causes endothelial…
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