483-Screening Organoids for Pancreas Acinar Specification
In this study, researchers utilized high-content, image-based screening to investigate the development and morphogenesis of human pancreatic organoids. By testing a library of small molecules, they identified 54 compounds that significantly alter cellular identity and physical structure, specifically focusing on the role of GSK3 inhibitors. The scientists discovered that activating WNT signaling while simultaneously suppressing FGF signaling drives pancreatic progenitors to differentiate into functional acinar cells. These findings are critical for understanding human organogenesis because…
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