130-Topological Velocity Inference from ST
This paper describes a new computational model called Topological Velocity Inference (TopoVelo), designed to jointly infer the spatial and temporal dynamics of cell fate transitions using spatial transcriptomic data. TopoVelo significantly advances existing RNA velocity frameworks by integrating spatial coupling among cells, modeling the entire tissue's dynamics through spatially coupled differential equations and graph neural networks (GNNs). The researchers apply TopoVelo to various biological systems, including the developing mouse cerebral cortex and neural tube closure, demonstrating…
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