1244-Loss of Transcriptional Coordination in Human Aging

Paper Talk · Jul 7, 2026 · 21m

This article investigates how gene expression coordination changes as humans age, revealing that cellular processes often lose their synchronized regulatory patterns over time. By developing a predictive network model trained on cancer cell line data, the researchers analyzed transcriptomic shifts across thirty human tissues to distinguish between simple expression noise and structured regulatory decline. Their findings indicate that while many gene relationships remain stable, weakening connections primarily occur between distinct cellular functions, whereas strengthening relationships often…