Mark Cuban: Disrupting the business of healthcare, part 2

20-Minute Health Talk · May 13, 2026 · 17m

In the second part of this conversation between 20-Minute Health Talk host Chethan Sathya, MD, and Mark Cuban, they discuss the twin forces reshaping healthcare: AI and price transparency. He argues that large language models can curb online health misinformation and even augment day-to-day clinical decisions. Cuban dives into policy, praising recent moves to rein in Medicare Advantage overpayments and explaining the drivers of branded drug costs in the U.S. He then unveils Cost Plus Wellness, a push to “open-source” direct contracts between self-insured employers and providers to reduce…