1646-Proteogenomic Landscapes of Non-Small Cell Lung Cancer
This research presents an extensive proteogenomic analysis of non-small cell lung cancer (NSCLC) to improve molecular subtyping and treatment precision. By utilizing mass spectrometry to examine 141 tumors, the authors identified six distinct proteome subtypes that reveal unique immune-evasion mechanisms and therapeutic targets. One significant finding links STK11 mutations to the activation of liver-specific genes like FGL1, a potential immune checkpoint ligand. The study also explores how global hypomethylation contributes to a high burden of non-canonical neoantigens in otherwise…
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