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Cancer Isn’t “Bad Luck” — It’s a Mitochondrial Energy Failure

In this The Energy Code Deep Dives episode, we challenge the standard “cancer is a genetic lottery” narrative and explore a different frame: cancer as a metabolic disease rooted in mitochondrial respiratory failure.

Using a 2025 mini-review from Journal of Bioenergetics and Biomembranes led by Thomas Seyfried, we revisit Otto Warburg’s original two-step hypothesis: damaged respiration (OXPHOS) → compensation via fermentation (even in oxygen). Then we unpack why a mid-century “oxygen consumption = healthy mitochondria” assumption derailed the field, and how modern data reframes that as a…

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