109-Mechanical confinement governs plasticity in melanoma
This excerpt from a scientific article details a study investigating how mechanical confinement in the tumor microenvironment drives phenotype switching in melanoma cells from a proliferative to an invasive and drug-resistant state. Using models including zebrafish melanoma and human cell lines, the researchers demonstrate that physical pressure causes melanoma cells to adopt an undifferentiated, neuronal-like identity. This process is mediated by the DNA-bending protein HMGB2, which is upregulated by confinement via a mechanism involving the LINC complex protein nesprin 2 and a stabilizing…
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