1325-Targeting FAM3D to Alleviate Atherosclerosis
The research identifies FAM3D as a cytokine-like protein that plays a critical role in the development of atherosclerosis in both humans and mice. Clinical data show that high levels of this protein in the blood serve as a predictor for coronary artery disease and early vascular pathology. The study reveals that FAM3D worsens the condition through two distinct pathways: a lipid-dependent mechanism that increases intestinal cholesterol absorption and a lipid-independent process involving vascular remodeling. Specifically, the protein activates the FPR1 signaling receptor to boost the…
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