541-Cancer-Derived Cystatin-C Attenuates Alzheimer’s Disease
This research explores the biological link between cancer and Alzheimer’s disease, investigating why cancer patients often exhibit a lower risk of neurodegeneration. By using 5×FAD mouse models, researchers discovered that peripheral tumors release specific secretory proteins that significantly reduce amyloid-beta accumulation and cognitive decline. Among these proteins, Cystatin-C (Cyst-C) was identified as a primary driver that crosses the blood-brain barrier to inhibit plaque formation. The study demonstrates that Cyst-C functions by binding to the TREM2 receptor on microglia, which…
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