What Longitudinal Data Actually Contains, with Shashi Shankar

The Clinical Realist · Sep 30, 2026 · 33m · transcript

Start with a number. In a registry of about 6,000 patients on GLP-1 medications, roughly 45 percent have taken two or more versions of the drug, most often moving from semaglutide to tirzepatide. The largest published study, about 127,000 adults, puts 12-month switching closer to 20 percent. Nobody can fully verify either figure, because no single system holds the whole record. Shashi Shankar spent nearly a decade at Genentech working on real world data before co-founding Novellia, where he is chief executive. The product pulls a patient's records out of every patient portal they have ever…