199-Restraint of Cancer Plasticity by Spatial Clustering
The sources present a scientific article from Cancer Cell detailing research on glioblastoma (GBM) cell behavior, specifically examining how the spatial arrangement of tumor cells influences their identity and plasticity. Using advanced single-cell resolution spatial transcriptomics and proteomics, the study found that when GBM cells are organized in homotypic clusters, their cellular state is stable, while dispersed cells exhibit greater plasticity and acquire alternative, more aggressive phenotypes. The authors identified different adhesion mechanisms, such as CD44 and NOTCH signaling, that…
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