118-Interferons in health and disease
This paper provides a comprehensive review of Interferons (IFNs), a class of signaling proteins crucial in health and disease. It details the three main types of IFNs (I, II, and III), highlighting their structural and functional differences, despite all signaling through Janus kinases. The review covers the cellular and molecular mechanisms of IFN induction and response, including the roles of pattern-recognition receptors (PRRs) and the subsequent activation of the JAK/STAT signaling pathway to produce interferon-stimulated genes (ISGs). Furthermore, the document extensively explores the…
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