479-Genetic Architecture of Aortic Valve Function

Paper Talk · Feb 6, 2026 · 16m

Scientists utilized deep learning and magnetic resonance imaging to analyze aortic valve function in nearly 60,000 participants from the UK Biobank. By measuring specific physical traits like peak velocity and aortic valve area, researchers identified 166 unique genetic loci linked to valve performance and the risk of aortic stenosis. The study discovered that many of the same genes influencing healthy valve function also drive the development of disease. Mendelian randomization further suggested that high levels of lipoproteins and blood pressure play a causal role in valve degradation…