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Dr. VK Gadi & Dr. Fengting Yan - Navigating HER2 Low and Ultra Low Disease

When the binary “HER2-positive vs HER2-negative” model collapsed under the weight of DESTINY-Breast04 and 06, the real work began: deciding who should receive trastuzumab deruxtecan (T-DXd), when to leapfrog chemotherapy, and how to keep quality of life front-and-center.

In this interactive Live from Seattle stream, translational researcher & clinician Dr. V.K. Gadi and high-volume breast oncologist Dr. Fengting Yan wrestle with that nuance in front of a virtual audience. Drawing on SABCS sub-analyses, ASCO 2025 biomarker updates, and their own experience and anecdotes, they outline a…

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