803-Determinants of B Cell Phenotype and Antibody Breadth
This research study examines the cellular and genetic factors that determine how broadly human antibodies can recognize different SARS-CoV-2 variants. By analyzing thousands of individual B cells from both vaccinated and previously infected individuals, the authors found that mRNA vaccination typically produces a more versatile immune response than natural infection. The data reveals that post-germinal center memory B cells, rather than atypical B cells, are the primary drivers of increased antibody breadth over time. Furthermore, the study identifies specific B cell receptor genes and…
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