108-Immune Dictionary at single-cell resolution

Paper Talk · Sep 30, 2025 · 16m

This paper presents a comprehensive study detailing the Immune Dictionary, a vast compendium of single-cell transcriptomic profiles mapping the responses of over seventeen immune cell types to eighty-six different cytokines in mouse lymph nodes in vivo. This research systematically reveals the highly cell-type-specific nature of cytokine responses and identifies over sixty-six distinct cytokine-driven cellular polarization states across the immune system. Furthermore, the authors introduce Immune Response Enrichment Analysis (IREA), a companion software designed to infer cytokine activity…