1345-Chromatin Landscape and Epigenetic Heterogeneity of AML

Paper Talk · Jul 27, 2026 · 22m

This study establishes an epigenetic classification system for acute myeloid leukaemia (AML) by analyzing the chromatin accessibility of over 1,500 patients. Using ATAC-seq technology, researchers identified 16 distinct subgroups that reveal critical insights into the disease's pathogenesis beyond traditional genetic mutations. These subgroups are defined by unique super-enhancer profiles and gene-regulatory networks driven by specific transcription factors. The findings demonstrate that this epigenomic framework more accurately reflects the differentiation states and clinical phenotypes of…