Global surge of early-onset Parkinson’s disease (EOPD)

Weekly Neurology Deep Dive - A review of recent impactful publications in the field of Neurology · Dec 20, 2025 · 11m

This research analyzes the global surge of early-onset Parkinson’s disease (EOPD) between 1990 and 2021, revealing that incidence and prevalence rates have nearly tripled worldwide. The study highlights a disproportionately high burden in Latin American countries, likely driven by specific genetic mutations and environmental factors such as arsenic contamination. While the disease is becoming more common globally, men and high-middle Socio-Demographic Index nations show the most significant increases in cases. The authors also explore the inverse relationship between smoking and EOPD, noting…