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New-onset refractory status epilepticus (NORSE) and febrile infection-related epilepsy syndrome (FIRES)
New-onset refractory status epilepticus (NORSE) and its subcategory, febrile infection-related epilepsy syndrome (FIRES), are rare clinical presentations characterized by the sudden onset of drug-resistant seizures in individuals without prior epilepsy. These conditions typically follow a biphasic course, beginning with a catastrophic acute phase of status epilepticus followed by a chronic phase of refractory epilepsy and significant cognitive impairment, and are increasingly viewed as immune-inflammatory-mediated encephalopathies involving innate immunity dysfunction. While acute management…
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