686-TGFβ-Induced Atypical EMT and Immune Mechanosurveillance
This research investigates how lung adenocarcinoma (LUAD) cells survive in a dormant state by utilizing a unique biological transition. While the TGFβ protein typically triggers a movement-oriented change in cancer cells, these specific progenitors instead adopt an atypical mesenchymal state characterized by a round shape and a lack of actin stress fibers. By producing a protein called gelsolin, these dormant cells soften their structure to become biomechanically less stiff, allowing them to hide from the immune system's mechanical detection. This structural softening effectively protects the…
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