1709-Lineage Tracing of Tumor Evolution and Plasticity
The paper introduce the KP-Tracer mouse model, an innovative genetic system designed to continuously track the evolution of lung adenocarcinoma at single-cell resolution. By combining Cas9-based lineage tracing with single-cell RNA sequencing, researchers can map the intricate phylogenetic relationships and fitness landscapes of developing tumors from a single transformed cell. The findings reveal that tumor expansion is driven by rare subclones acquiring specific transcriptional profiles and DNA copy number variations, often progressing through distinct gene modules associated with cellular…
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