Pharma 11: Nicotinic Signalling - Junctions, Gates, and Thresholds

Clinical Deep Dives · Jan 31, 2026 · 1m

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This episode examines nicotinic receptor pharmacology at two critical crossroads: autonomic ganglia and the neuromuscular junction. Here, signalling is rapid, decisive, and threshold-dependent—very different from the modulatory tone of muscarinic systems. We explore how drugs that act at nicotinic receptors can stimulate, block, or exhaust transmission,…