1650-Universal TumorDressed Dendritic Cells as Vaccine
Researchers have developed a personalized cancer vaccine platform by transforming universal, genetically engineered induced pluripotent stem cells (hiPSCs) into functional dendritic cells. These specialized immune cells are "dressed" with MHC-antigen complexes extracted from a patient's own tumor membranes, allowing them to present a complete profile of cancer markers to the immune system. To optimize effectiveness, scientists used CRISPR-Cas9 to remove endogenous MHC molecules, preventing the vaccine from being rejected as foreign while ensuring it specifically activates tumor-killing T…
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