994-SAMENT: Mapping Niche in Bone Metastasis
The research article introduces SAMENT, a sophisticated tool designed to map the microenvironment niches surrounding metastatic cancer cells with high precision. By using a bacterial enzyme to tag neighboring cells, this method identifies specific cellular and molecular interactions that occur during the spread of cancer to various organs. The study reveals that metastatic sites are consistently enriched with macrophages and depleted of T cells, creating an immune-excluded environment that protects the tumor. Specifically, the researchers discovered that direct contact with cancer cells…
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