1500-Arginine Availability Controls MHC-I Translation
This research illustrates how arginine availability serves as a master regulator of the immune system by controlling the translation of MHC class I proteins. When arginine levels are depleted by diseases like colon cancer or respiratory viruses such as SARS-CoV-2, ribosomes stall at specific arginine codons, leading to reduced antigen presentation and immune escape. Conversely, increasing this amino acid through dietary supplementation or genetic modification enhances the production of these critical immune proteins, thereby improving the body's ability to fight tumors and infections. The…
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