970-Spatial 5mC-seq Profiling of Embryos and Decidua
This paper describes the creation of SmC-seq, a groundbreaking microfluidic-based technology designed to map DNA methylation across tissue sections while maintaining spatial orientation. By applying this method to mouse embryos during the post-implantation stage, researchers successfully identified how epigenetic patterns shift within specific anatomical regions. The study reveals a distinct spatial heterogeneity in DNA methylation between maternal and embryonic tissues, highlighting a unique low-methylation state in certain maternal cells that support nutrient provision. These findings…
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