Microglia May Hold Key to Dementia Resilience | Health and Fitness News

Health News Today | 2 Min News | The Daily News Now! · Jul 26, 2026 · 1m

Scientists have pinpointed a crucial brain tipping point that may explain why some people with Alzheimer’s pathology never develop dementia—thanks to microglia, the brain’s immune cells. Research using human tissue reveals that microglia shift from an early inflammatory response to a later, more damaging state, and this transition appears to determine whether cognitive decline follows. Remarkably, some individuals with significant plaques and tangles remain sharp because their microglia avoid this harmful shift, while centenarians activate it without triggering tau buildup—suggesting the…