506-scRank: Inferring Drug-Responsive Cell Types

Paper Talk · Feb 15, 2026 · 16m

Researchers introduced scRank, a computational tool using single-cell transcriptomics and gene regulatory networks to identify drug-targeted cell types. They identified Ex_9 neurons as targets for SSRIs in MDD and found that Tanshinone IIA binds CTSB in macrophages.

References:

scRank infers drug-responsive cell types from untreated scRNA-seq data using a target-perturbed gene regulatory networkLi, Chengyu et al.Cell Reports Medicine, Volume 5, Issue 6, 101568

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