924-Cycling Treg & cDC2 for Breast Cancer Immune Escape
This research identifies a specific cell population known as cycling regulatory T cells (cycTreg) as the primary driver of immune suppression during the transition from ductal carcinoma in situ (DCIS) to invasive breast cancer (IBC). By utilizing single-cell transcriptomics and spatial mapping across human cohorts and rat models, the authors demonstrate that type 2 dendritic cells (cDC2) and IL-33-producing fibroblasts stimulate the expansion of these suppressive cells. Clinical data reveal that cycTreg levels serve as a powerful diagnostic biomarker, predicting a higher risk of recurrence in…
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