Latest / Weekly Neurology Deep Dive - A review of recent impactful publications in the field of Neurology
Neurological Involvement in Merkel Cell Carcinoma
This clinical review examines the neurological complications associated with Merkel cell carcinoma (MCC), distinguishing between immune-mediated paraneoplastic syndromes and direct metastatic involvement. The text highlights that Lambert–Eaton myasthenic syndrome (LEMS) is the most frequent paraneoplastic manifestation and often appears before the cancer is officially diagnosed. Diagnostic protocols emphasize the use of paired serum and CSF antibody testing, specifically looking for VGCC, anti-Hu, and neurofilament antibodies to identify underlying malignancy. Management of these conditions…
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