369-An Integrated Atlas of the Human Vascular System
This study introduces a comprehensive human vascular cell atlas that maps the molecular profiles of endothelial and mural cells across various organs and tissues. By utilizing single-cell RNA sequencing and spatial transcriptomics, the researchers identified significant functional diversity and tissue-specific adaptations within the circulatory system. Their findings highlight how specialized cells, such as those in the brain-blood barrier or the splenic littoral system, possess unique genetic signatures. The researchers also employed a tool called drug2cell to predict how specific…
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