Micro 41: Papillomaviruses and Polyomaviruses
This episode begins the virus-family–specific chapters with two groups of small, non-enveloped DNA viruses: papillomaviruses and polyomaviruses. Drawing from Murray’s Chapter 41, it explores their structural simplicity and profound clinical consequences.
The narrative centres first on Human Papillomavirus (HPV). These viruses infect stratified squamous epithelium, producing benign warts or, in high-risk strains, driving oncogenic transformation. The viral proteins E6 and E7 interfere with tumour suppressor pathways, linking infection to cervical, anogenital, and oropharyngeal cancers…
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