Long-term outcomes of seizures and epilepsy in patients with untreated cerebral cavernous malformations

Weekly Neurology Deep Dive - A review of recent impactful publications in the field of Neurology · Dec 14, 2025 · 11m

This prospective, population-based cohort study focuses on the long-term outcomes of seizures and epilepsy in patients with untreated cerebral cavernous malformations (CCMs). The research tracked 300 patients in Scotland for a median of 15 years to assess the risk of developing seizures and experiencing seizure recurrence without surgical intervention for the CCMs. Key findings include that the risk of a first-ever epileptic seizure from a CCM is low, but the risk of seizure recurrence after a first unprovoked seizure is notably high (80% within 10 years), which justifies the diagnosis of…