552-Armored Anti-TREM2 CAR T Cells for Solid Tumor
The provided source describes the development of a novel CAR T cell therapy specifically designed to treat solid tumors by targeting the tumor microenvironment rather than the cancer cells themselves. Researchers identified TREM2 as a protein highly expressed on immunosuppressive macrophages across various cancers, making it an ideal target for clearing the cells that normally protect tumors from the immune system. To increase potency, these T cells were "armored" with a synthetic biosensor that triggers the localized release of interleukin-12 (IL-12) only when the cells encounter their…
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